WiseCure____________________________________________________

 

Wireless, Scalable and Implantable Optogenetics for Neurological Disorders Cure (H2020-MSCA-IF-2019; GA n.893822) 

(November 2020 - October 2022)Horizon20201

 

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This WiseCure Fellowship aims to develop novel wireless, scalable, MRI-compatible, and biointegrated neural implants for optogenetics to treat neurological diseases 

 

WHY?

Neurological disorders are diseases of the central and peripheral nervous system. Hundreds of millions of people worldwide are affected by neurological disorders. The ability to decipher brain functions and understand the neuronal communication networking properties to develop innovative solutions holds the key to treat such neurological diseases.


Asset 1OPTOGENETICS

Optogenetics  is a neural modulation technique which utilizes light to stimulate genetically engineered neurons, providing a better option for controlling the neurons compared to conventional electrical stimulation.

CHALLENGES

Scientists pursuing optogenetic therapies still face some technical challenges (e.g. size and multifunctional capability, biointegration, wireless capability, Magnetic Resonance Imaging (MRI) compatibility that keeping optogenetics from clinical trials for brain diseases. This Fellowship will combine the innovative wireless power transfer (WPT) approaches with ultrathin, soft and flexible biocompatible polymeric platforms to fabricate and characterize neural implants that are small enough to promote scalability, chronic reliability, and MRI compatibility. 

FIg 1OBJECTIVES

The objectives of this Fellowship, which complement each other in terms of research (Obj1-Obj3) and training (Obj4) are given below: 

  • Obj1) Develop unique self-tracked WPT system for optogenetics. 
  • Obj2) Achieve versatile wireless optogenetics control using neural implants via a smart device. 
  • Obj3) Validate MRI-compatible and biointegrated neural implants to enable chronic in vivo optogenetics. 
  • Obj4) Advance the career toward becoming a recognized research leader in neural engineering, and act as an ambassador for Marie Skłodowska-Curie Actions (MSCA). 

RESULTS & OUTREACH

  • In preparation: R. Das, E. McGlynn, M. Yuan and H. Heidari, "Soft, flexible and stretchable serpentine shaped metamaterials wireless energy harvester with unity efficiency", IEEE Transactions on Microwave Theory and Techniques

More Exciting Research will follow....Keep following!!

 

PEOPLE

 RupamRUPAM DAS (Marie Skłodowska-Curie Fellow)

I am a Biomedical engineer with a strong background in biomedical implantable devices and electromagnetic theories. I hold a MSc and a PhD in Electrical Engineering, received from the University of Ulsan, South Korea. My current research focuses on the development of wireless neural implants. 

My futuristic vision  is to integrate the wireless neuromodulating system into smart healthcare using mobile and electronic technology for betterdiagnosis of the brain diseases, improved treatment, and enhanced quality of lives.

 

Hadi new HADI HEIDARI (Supervisor)

I am an engineer and I hold a PhD in Microelectronics. My research is motivated by the potential of technology for diagnosis and treatment of neurological disorders. I have a strong expertise in wearable and implantable microelectronic devices acquired both in academia and industry.

I lead the Microelectronics lab at the University of Glasgow, where we focus on miniaturizing devices for implantable microelectronics and on neural interfaces.

 

Giulia Bio a887eee9GIULIA CURIA (Supervisor at the Seconding Institution)

I hold a MSc in Biological Sciences and a PhD in General Physiology. After several years of international experience, I returned to Italy and established myself at UNIMORE thanks to the program "Rientro dei Cervelli". I have a strong background in epilepsy research, by means of in vitro and in vivo  electrophysiology, built across 20 years of national and international experience. 

 

Eve McGlynn webEVE McGLYNN (Collaborator)

I graduated from the University of Glasgow in 2019 with an MEng in Electronics and Electrical Engineering. My experience is in antenna design, and I have a keen interest in electromagnetics.

Currently, I am involved in the fabrication and encapsulation of implantable neural probes for recording and brain stimulation.

 

HUXI WANG (Collaborator)

FINLAY WALTON (Collaborator)

 

INSPIRED BY

  • Deisseroth, K. "Optogenetics". Nat Methods 8, 26–29 (2011). https://doi.org/10.1038/nmeth.f.324
  • R. Das, A. Basir and H. Yoo, "A Metamaterial-Coupled Wireless Power Transfer System Based on Cubic High-Dielectric Resonators," in IEEE Transactions on Industrial Electronics, vol. 66, no. 9, pp. 7397-7406, Sept. 2019, doi: 10.1109/TIE.2018.2879310.
  • R. Das, F. Moradi and H. Heidari, "Biointegrated and Wirelessly Powered Implantable Brain Devices: A Review," in IEEE Transactions on Biomedical Circuits and Systems, vol. 14, no. 2, pp. 343-358, April 2020, doi: 10.1109/TBCAS.2020.2966920.
  • J. A. Rogers et al., "Stretchable multichannel antennas in soft wireless optoelectronic implants for optogenetics" PNAS (2016) 113 (50) E8169-E8177.
  • J. S. Ho et al.,"Self-tracking energy transfer for neural stimulation in untethered mice" Phys. Rev. Applied 4, 024001, 2015